Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease

EVEREKLİOĞLU C., Er H., Turkoz Y., ÇEKMEN M. B.

MEDIATORS OF INFLAMMATION, cilt.11, sa.2, ss.87-93, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1080/09629350220131935
  • Dergi Adı: MEDIATORS OF INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.87-93
  • Anahtar Kelimeler: Behcet's disease, chemokine, cytokine, immunoassay, interleukin, lipid peroxidation, ACUTE-PHASE RESPONSE, ENDOTOXIN-INDUCED UVEITIS, TUMOR-NECROSIS-FACTOR, IMMUNOASSAY SYSTEM, CYTOKINE, INTERLEUKIN-8, INVOLVEMENT, CELLS, RAT
  • İnönü Üniversitesi Adresli: Evet

Özet

AIM Behcet's disease (BD) is a systemic immunoinflammatory disorder and the aetiopathogenesis is to be specified. Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case-control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha, interleukin-1beta (IL-1beta), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 levels in patients with BD. We also determined the end product of lipid peroxidation (malondialdehyde (MDA)) in BD patients as an index for oxidative stress.