Histological assessment of liver and stomach damage caused by pyridazinone derivative antidepressant agents

ÖZDEMİR Z., KARAKURT A., TAŞLIDERE E., VARDI N., ALAGÖZ M. A., PARLAKPINAR H., ...Daha Fazla

BIOTECHNIC & HISTOCHEMISTRY, cilt.97, sa.5, ss.355-362, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 97 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/10520295.2021.1999499
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.355-362
  • Anahtar Kelimeler: Antidepressant, histopathology, liver, mice, pyridazinone, stomach, swimming test, FORCED SWIMMING TEST, SERIES
  • İnönü Üniversitesi Adresli: Evet

Özet

Depression is a serious psychological disorder that affects a significant population. We investigated the antidepressant activities of four pyridazinone derivatives that contain the hydrazide moiety using the forced swimming test (FST). The compounds tested exhibited good antidepressant activity compared to duloxetine. The most promising compound was compound 2, which reduced the duration of immobility during FST. The toxic effects of the four compounds on the histomorphology of the liver and stomach tissue also was evaluated.