Neuroprotective effect of mexiletine in the central nervous system of diabetic rats

Ates O., Cayli S. R., Altinoz E., Yucel N., Kocak A., Tarim O., ...Daha Fazla

MOLECULAR AND CELLULAR BIOCHEMISTRY, cilt.286, ss.125-131, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 286
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s11010-005-9102-6
  • Dergi Adı: MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.125-131
  • Anahtar Kelimeler: central nervous system, diabetes mellitus, mexiletine, lipid peroxidation, oxidative damage, streptozotocin, CNS WHITE-MATTER, NITRIC-OXIDE FORMATION, XANTHINE-OXIDASE, OXIDATIVE STRESS, ANOXIC INJURY, NA+ CHANNELS, GENERATION, PROTECT, CORTEX, CELLS
  • İnönü Üniversitesi Adresli: Evet

Özet

Both experimental and clinical studies suggests that oxidative stress plays an important role in the pathogenesis of diabetes mellitus type I and type 2. Hyperglycaemia leads to free radical generation and causes neural degeneration. In the present study we investigated the possible neuroprotective effect of mexiletine against streptozotocin-induced hyperglycaemia in the rat brain and spinal cord.